Application of Lithium in Medical Field

When wolves eat meat containing lithium compounds, it can cause indigestion and greatly reduce appetite, thus changing the habit of wolves eating meat, which is also hereditary.

The application of lithium metal has made a good start, but the production process of lithium is complicated and the cost is high. Once these problems are solved, the excellent performance of lithium will be further developed, thereby expanding its scope of application.

Lithium can improve hematopoietic function, improve the body's immune function. Lithium has a regulatory effect on central nervous activity, can calm, soothe the nerves, and control neurological disorders. Lithium can replace sodium, prevention and treatment of cardiovascular disease. The human body needs about 0.1mg of lithium daily intake.

Biological necessity and human health effects of lithium. Lithium is an effective mood stabilizer. With the advent of new mood stabilizers, interest and research in lithium therapy has declined, but lithium remains the most effective measure for the treatment of acute mania and the preventive management of manic-depressive illness. Many studies have demonstrated that lithium has essential functions or beneficial effects in animals and humans. Lithium deficiency in animals can lead to shortened lifespan, reproductive abnormalities, behavioral changes, and other abnormalities. Human epidemiological studies have shown that the concentration of lithium in drinking water is significantly negatively correlated with the rate of psychiatric hospitalization, homicide, suicide, robbery, violent crime and drug crime. Studies of nutritional lithium supplements by drug offenders have shown that lithium can improve and stabilize mood. Patients with heart disease, learning impotence and violent offenders in custody had significantly lower lithium levels. The clinical research of lithium carbonate treatment shows that the main reaction organs of lithium are gastrointestinal tract, kidney, nerve, muscle, endocrine and cardiovascular system. In the therapeutic dose range of 170-228mg Li/d, the expected serum lithium level is 0.4-0.8 mEq/L(2.78-5.55 mg/L) with no toxic effects. In the risk assessment of lithium, the use of 10 times the safety factor for the treatment dose does not cause harm to the pregnant woman and fetus, which is equivalent to the adult intake of 2mg Li per day. The NOAEL (level of non-toxic effect) of the animals was 10 mgLi/kg/d, resulting in an allowable daily intake (ADI) of 0.31mgLi/kg/d using a 32-fold safety factor. Based on animal experimental data, the apparent deficient intake of lithium was: goat:<1.5mg Li/kg, rat:<15 μg Li/kg. The dietary requirement of human lithium is about 60~100 μg/d, and the typical daily intake is 200~600 μg. Eggs, milk, dairy products, fish, potatoes and vegetables are rich in lithium.